How Oxidized Low-Density Lipoprotein Activates Inflammatory Responses
نویسندگان
چکیده
منابع مشابه
Oxidized low-density lipoprotein in postmenopausal women.
BACKGROUND Oxidized low-density lipoprotein (oxLDL) leads to atherosclerosis and cardiovascular disease, the most frequent causes of death worldwide. After menopause, lipid and lipoprotein metabolism changes and women are at greater risk of cardiovascular disease compared to fertile women. The aim of this study was to determine the prevalence of serum oxLDL in postmenopausal women and to identi...
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Apoptosis of arterial cells induced by oxidized low density lipoproteins (OxLDL) is thought to contribute to the progression of atherosclerosis. However, most data on apoptotic effects and mechanisms of OxLDL were obtained with extensively oxidized LDL unlikely to occur in early stages of atherosclerotic lesions. We now demonstrate that mildly oxidized LDL generated by incubation with oxygen ra...
متن کاملOxidized low-density lipoprotein activates adipophilin through ERK1/2 signal pathway in RAW264.7 cells.
It has been reported that oxidized low-density lipoprotein (Ox-LDL) can increase the expression of adipophilin. However, the detailed mechanisms are not fully understood. The aim of this study was to investigate the mechanism of Ox-LDL on adipophilin expression and the intracellular lipid droplet accumulation. A mouse macrophage-like cell line, RAW264.7, was used throughout, and it was found th...
متن کاملA macrophage receptor that recognizes oxidized low density lipoprotein but not acetylated low density lipoprotein.
The formation of cholesterol-loaded macrophage foam cells in arterial tissue may occur by the uptake of modified lipoproteins via the scavenger receptor pathway. The macrophage scavenger receptor, also called the acetylated low density lipoprotein (Ac-LDL) receptor, has been reported to recognize Ac-LDL as well as oxidized LDL species such as endothelial cell-modified LDL (EC-LDL). We now repor...
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ژورنال
عنوان ژورنال: Critical Reviews in Immunology
سال: 2018
ISSN: 1040-8401
DOI: 10.1615/critrevimmunol.2018026483